The consequences of concomitant use or discontinuation of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with codeine are complex, requiring mindful consideration of the effects about the parent drug, codeine, and also the active metabolite, morphine.
Prevent the usage of promethazine HCl and codeine phosphate oral Answer in adolescents 12 to 18 yrs of age who have other possibility variables which will increase their sensitivity to the respiratory depressant effects of codeine Except the advantages outweigh the challenges.
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Steer clear of the usage of promethazine HCl and codeine phosphate oral Answer in individuals who are having CYP3A4 inducers. If concomitant usage of a CYP3A4 inducer is important, follow the client for lowered efficacy.
Postmarketing scenarios of respiratory despair, like fatalities have already been reported with usage of promethazine in pediatric people.
FDA Drug Protection Interaction: FDA restricts utilization of prescription codeine ache and cough medicines and tramadol pain medicines in young children; suggests versus use in breastfeeding Girls
Increased force as part of your head (enhanced intracranial pressure). Stay away from the use of Promethazine Hydrochloride and Codeine Phosphate Oral Remedy Should you have a head personal injury or are advised that you have improvements inside the tissue of your respective Mind (Mind lesions) or amplified stress with your head.
Prior to taking this medication, tell your physician or pharmacist In case you are allergic to any of its substances; or to opioid agony relievers (which include morphine); or When you've got another allergic reactions.
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Drug interactions, like an elevated incidence of extrapyramidal consequences, are actually reported when some MAOI and phenothiazines are utilized concomitantly.
Customers will chase the large, making use of A lot more with the drug right until the human body will become dependent upon it. As soon as that happens, buyers are more likely to turn into addicted, suffering from cravings and withdrawal symptoms every time they test to prevent using it.
Promethazine and codeine blend is utilised To alleviate cough, runny or stuffy nose, sneezing, or other indicators due to allergic reactions or even the typical chilly.
In Women of all ages with normal codeine metabolism (regular CYP2D6 activity), the amount of codeine secreted into human milk is minimal and dose-dependent. There is absolutely no information on the results on the codeine on milk creation.